Ammonia → HCID 21527600, compound

Participants

Reaction Steps

1 g of 4-(3-tert-butylamino-2-hydroxypropoxy)oxindole is dissolved in 20 cc of hexamethylphosphoric acid triamide and the solution is allowed to stand at room temperature for 16 hours together with 7.9 g of benzoic acid and 0.9 g of benzoic acid anhydride. The mixture is poured into ice water, is rendered alkaline with a 10% ammonia solution and is extracted with methylene chloride. The title compound is obtained as evaporation residue of the methylene chloride phase; the hydrogen oxalate of the title compound crystallizes from ethanol. M.P. 200°-203°.

Provenance & Evidence