Chloromethyl methyl carbonate → HCID 178502571, compound

HRID 1658490Notes

Reaction equation

HRID 1658490 reaction equation
[C:1](=[O:7])([O:5][CH3:6])[O:2][CH2:3]Cl.[F:8][C:9]([S:12][CH2:13][C:14]([NH:16][CH:17]1[C:35](=[O:36])[N:19]2[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH:24]([S:26][C:27]3[NH:31][N:30]=[N:29][N:28]=3)[CH3:25])[CH2:22][S:23][C@H:18]12)=[O:15])([F:11])[F:10].[Na]>CN(C=O)C>[F:8][C:9]([S:12][CH2:13][C:14]([NH:16][CH:17]1[C:35](=[O:36])[N:19]2[C:20]([C:32]([O:34][CH2:3][O:2][C:1]([O:5][CH3:6])=[O:7])=[O:33])=[C:21]([CH:24]([S:26][C:27]3[NH:28][N:29]=[N:30][N:31]=3)[CH3:25])[CH2:22][S:23][C@H:18]12)=[O:15])([F:11])[F:10]

Participants

4

Reactant 2

HCID 14787050Chloromethyl methyl carbonateHCID 178477396HCID 178477396, compound

Product 1

HCID 178502571HCID 178502571, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Chloromethyl methyl carbonate (0.02 mol) is reacted with sodium 7-trifluoromethylmercaptoacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (0.01 mol) in DMF for 20 hours. On work up as described in Example 1, methoxycarbonyloxymethyl 7-trifluoromethylmercaptoacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate is obtained.

Sources & evidence

ORD record
ord-495500dcb2e14f91a7d9233d0158e9c6
Source dataset
uspto-grants-1976_06
Patent number
US03965099

Reaction notes

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