反应详情

When a mixture of 0.5 mole each of 1,3-dimethylurea, triphenyl phosphite, and 3-methylthiopropionaldehyde in 100g of toluene is warmed to 75°, a reaction is initiated and the temperature increases rapidly to 120°. After further warming at 105° for 1 hr, the resulting yellow product has a 31P nmr signal at -28.2 ppm for the cyclic ester, 1,4-dimethyl-3-(2-methylthioethyl)-2-phenoxy-1,4,2-diazaphospholidin-5-one-2-oxide. The above product is then employed in a toluene solution from which byproduct phenol is removed by stripping to 110° /1 mm, after which one-third of the residue is dissolved in 75ml of acetonitrile and 10g of water, and this solution is refluxed for 3 hr. The reaction mixture is allowed to evaporate to dryness, and the residue is extracted with ether and then with hot acetonitrile and recrystallized twice from acetic acid to give a white solid: mp 164.5°-167°; 31P nmr (DMSO-d6) -21.4 ppm; 1H nmr 9.6 (broad, 2, OH), 4.5 (m, 1, PCH), 2.8 (s, NCH3), 2.6 (s, NCH3), 2.0 (s, SCH3), 1.9-2.6 (m, CH2CH2S).

1. temperatureis warmed to 75°
2. temperaturethe temperature increases rapidly to 120°
3. temperatureAfter further warming at 105° for 1 hr
4. customis removed
5. customby stripping to 110°
6. dissolutionafter which one-third of the residue is dissolved in 75ml of acetonitrile
7. temperature10g of water, and this solution is refluxed for 3 hr
8. customto evaporate to dryness
9. extractionthe residue is extracted with ether
10. customwith hot acetonitrile and recrystallized twice from acetic acid
11. customto give a white solid