N-Acetyl-L-Cysteine → HCID 22791110, compound

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Reaction Steps

N-acetyl-L-cysteine ammonium salt can also be obtained by modification of the above procedure as follows. About 6.5 ml. of concentrated ammonium hydroxide is added slowly to a stirred mixture of N-acetyl-L-cysteine (16.3 g., 0.1 mole) in 100 ml. of water. The pH of the mixture should be 7 at the end of the addition. The solvent is allowed to evaporate and the white residue thus obtained when dried to constant weight at 45°C. in vacuo over phosphorous pentoxide provides a quantitative yield (18 g.,) of analytically pure ammonium N-acetyl-L-cysteinate, M.P. 148°- 150°C. (dec.), [ α ]D25 + 20.3°(c 5,H2O).

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