N-Acetyl-L-Cysteine → HCID 22791110, compound

HRID 1658588Notes

Reaction equation

HRID 1658588 reaction equation
[OH-].[NH4+:2].[C:3]([NH:6][C@H:7]([C:10]([OH:12])=[O:11])[CH2:8][SH:9])(=[O:5])[CH3:4]>O>[C:3]([NH:6][C@H:7]([C:10]([O-:12])=[O:11])[CH2:8][SH:9])(=[O:5])[CH3:4].[NH4+:2]

Participants

4

Reactant 2

HCID 12035N-Acetyl-L-CysteineHCID 14923Ammonium Hydroxide

Product 1

HCID 22791110HCID 22791110, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-acetyl-L-cysteine ammonium salt can also be obtained by modification of the above procedure as follows. About 6.5 ml. of concentrated ammonium hydroxide is added slowly to a stirred mixture of N-acetyl-L-cysteine (16.3 g., 0.1 mole) in 100 ml. of water. The pH of the mixture should be 7 at the end of the addition. The solvent is allowed to evaporate and the white residue thus obtained when dried to constant weight at 45°C. in vacuo over phosphorous pentoxide provides a quantitative yield (18 g.,) of analytically pure ammonium N-acetyl-L-cysteinate, M.P. 148°- 150°C. (dec.), [ α ]D25 + 20.3°(c 5,H2O).

Workup

  1. additionat the end of the addition
  2. customto evaporate
  3. customthe white residue thus obtained when
  4. dry with materialdried to constant weight at 45°C. in vacuo over phosphorous pentoxide

Sources & evidence

ORD record
ord-a22fcff2296d42d5b7419136abac50c2
Source dataset
uspto-grants-1976_06
Patent number
US03965167

Reaction notes

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