Hydrochloric Acid → HCID 178484892, compound

Participants

Reaction Steps

To a solution of 38.1 g. (0.1 moles) of N1 -methyl-N2 -(4-bromo-3-trifluoromethylphenyl)-2-acetoxy isobutyramidine in 500 ml. of ethanol, add 5.6 g. (0.1 moles) of potassium hydroxide, maintaining the reaction at room temperature. Stir at room temperature for several hours (until there is no evidence of starting ester by tlc). Remove the solvent in vacuo, partition the residue between ether and water, dry the ether extract over sodium sulfate, filter, and precipitate the product of this reaction as its hydrochloride salt, by adding 25 ml. of 4.0N ethereal hydrogen chloride.

Provenance & Evidence