Hydrochloric Acid → HCID 178484892, compound

HRID 1658673Notes

Reaction equation

HRID 1658673 reaction equation
[CH3:1][NH:2][C:3](=[N:11][C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[C:14]([C:19]([F:22])([F:21])[F:20])[CH:13]=1)[C:4]([O:7]C(=O)C)([CH3:6])[CH3:5].[OH-].[K+].Cl>C(O)C>[CH3:1][NH:2][C:3](=[N:11][C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[C:14]([C:19]([F:20])([F:21])[F:22])[CH:13]=1)[C:4]([OH:7])([CH3:6])[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 178484893HCID 178484893, compound

Product 1

HCID 178484892HCID 178484892, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 38.1 g. (0.1 moles) of N1 -methyl-N2 -(4-bromo-3-trifluoromethylphenyl)-2-acetoxy isobutyramidine in 500 ml. of ethanol, add 5.6 g. (0.1 moles) of potassium hydroxide, maintaining the reaction at room temperature. Stir at room temperature for several hours (until there is no evidence of starting ester by tlc). Remove the solvent in vacuo, partition the residue between ether and water, dry the ether extract over sodium sulfate, filter, and precipitate the product of this reaction as its hydrochloride salt, by adding 25 ml. of 4.0N ethereal hydrogen chloride.

Workup

  1. customthe reaction at room temperature
  2. customRemove the solvent in vacuo
  3. custompartition the residue between ether and water
  4. dry with materialdry the ether
  5. extractionextract over sodium sulfate
  6. filtrationfilter
  7. customprecipitate
  8. customthe product of this reaction as its hydrochloride salt
  9. additionby adding 25 ml

Sources & evidence

ORD record
ord-38e41d60eb474eb5bb593ef66fa5ea71
Source dataset
uspto-grants-1976_06
Patent number
US03965176

Reaction notes

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