2-Mercaptoethanol → HCID 53649238, compound

HRID 1658677Notes

Reaction equation

HRID 1658677 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([S:10][CH2:11][C:12](O)=[O:13])=[S:9])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].SCCO>[OH-].[Na+]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([S:10][CH2:11][CH2:12][OH:13])=[S:9])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 15672-MercaptoethanolHCID 516892Sodium BicarbonateHCID 54194572HCID 54194572, compound

Product 1

HCID 53649238HCID 53649238, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Crude carboxymethyl 4-aminobenzenecarbodithioate (7.48 g, 0.033 mole) was dissolved in 0.5 N (66 ml) sodium hydroxide solution containing 10% by weight of sodium bicarbonate and the solution was filtered to remove traces of insoluble material. 2-Mercaptoethanol (2.9 g, 0.037 mole) was added to the stirred filtrate and the reaction mixture soon became turbid as the product began to separate out. After standing for 1 hour at room temperature, the orange precipitate was filtered off, washed with water, and dried in vacuo at a temperature of below 50°C. The yield of the product, an orange crystalline powder, m.p. 87.5°-89.5° was 6.13 g or 87%.

Workup

  1. filtrationthe solution was filtered
  2. customto remove traces of insoluble material
  3. customto separate out
  4. filtrationthe orange precipitate was filtered off
  5. washwashed with water
  6. customdried in vacuo at a temperature of below 50°C

Sources & evidence

ORD record
ord-aa1d6407a4e34a86b376f950e7122b16
Source dataset
uspto-grants-1976_06
Patent number
US03966397

Reaction notes

Loading…