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HRID1658706

反应详情

EQUATION

反应方程式

HRID 1658706 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(=O)O[C@H]1CC[C@H]2[C@@H]3[C@@H]4O[C@@H]4C4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](F)C[C@]12C
HCID86733596

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@H]1CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](F)C[C@]12C
HCID68146617

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

500 mg. of 17β-acetoxy-6α,7α-epoxy-11β-fluoro-4-androsten-3-one is introduced at room temperature into 25 ml. of glacial acetic acid saturated with gaseous hydrogen chloride. After 24 hours, the solution is poured into ice/water. The thus-precipitated product is vacuum-filtered, taken up in methylene chloride, washed with water, and dried. After recrystallization of the crude product from acetone/hexane, 210 mg. of 17β-acetoxy-6-chloro-11β-fluoro-4,6-androstadien-3-one is obtained. UV: ε283 = 20,300.

WORKUP

后处理

  1. filtrationThe thus-precipitated product is vacuum-filtered
  2. washwashed with water
  3. customdried
  4. customAfter recrystallization of the crude product from acetone/hexane, 210 mg