Methyl iodide → HCID 21387767, compound

HRID 1658727Notes

Reaction equation

HRID 1658727 reaction equation
[Na].[CH3:2][O-:3].[Na+].CS[C:7]1[N:12]([NH2:13])[C:11](=[O:14])[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:9][N:8]=1.CI>CO>[CH3:2][O:3][C:7]1[N:12]([NH2:13])[C:11](=[O:14])[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:9][N:8]=1

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 122957854-Amino-3-methylthio-6-phenyl-1,2,4-triazine-5-one

Product 1

HCID 21387767HCID 21387767, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.3 g sodium are added to 500 ml methanol whereby a sodium methylate solution is formed. 23.4g 3-methylthio-4-amino-6-phenyl-1,2,4-triazine-5-one (1a) and 6.5 ml methyl iodide are added. The mixture is boiled for one hour. When cooling down the mixture, a crystalline precipitate separates. The crystals are removed by suction and recrystallized from methanol and optionally once more from acetic acid ester. The 3-methoxy-4-amino-6-phenyl-1,2,4-triazin-5-one (33") thus obtained has a melting point of 167°C.

Workup

  1. customis formed
  2. temperatureWhen cooling down the mixture
  3. customThe crystals are removed by suction
  4. customrecrystallized from methanol and optionally once more from acetic acid ester

Sources & evidence

ORD record
ord-c0ddec3d06e54b8186e5456b27d9c681
Source dataset
uspto-grants-1976_06
Patent number
US03966715

Reaction notes

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