反应详情

To a solution of 161.0 g of α, α, α-trifluoro-m-toluidine in 500 ml of 2N hydrochloric acid, at room temperature, with vigorous agitation, is added rapidly 102.0 g of acetic anhydride. An exothermic reaction occurs and the temperature is allowed to rise spontaneously to about 50°. Subsequently, the mixture is allowed to cool to room temperature, and then cooled in ice. The crystalline solid is filtered to give 189.3 g of α,α,α-trifluoro-m-acetotoluidide.

1. customAn exothermic reaction
2. customto rise spontaneously to about 50°
3. temperaturecooled in ice
4. filtrationThe crystalline solid is filtered