1-Methylpiperazine → HCID 3041885, compound

HRID 1658743Notes

Reaction equation

HRID 1658743 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[S:6][C:7]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:8]=3[CH:9](Cl)[CH2:10][C:4]=2[CH:3]=1.[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[S:6][C:7]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:8]=3[CH:9]([N:23]3[CH2:24][CH2:25][N:20]([CH3:19])[CH2:21][CH2:22]3)[CH2:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 12232370HCID 12232370, compound

Product 1

HCID 3041885HCID 3041885, compound

Procedure

In the same manner as described in example 3, starting from 2,10-dichloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin and N-methylpiperazine, there is obtained 1-[2-chloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl]-4-methyl-piperazine which melts at 118°-120°. After recrystallisation of this base from ether and reaction with maleic acid the corresponding maleate is obtained which melts at 174°-175°.

Sources & evidence

ORD record
ord-f925880247804c688bf5f788a72055b0
Source dataset
uspto-grants-1976_06
Patent number
US03966737

Reaction notes

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