3-(4-Fluorobenzoyl)propyl chloride → HCID 68130838, compound

HRID 1658800Notes

Reaction equation

HRID 1658800 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6].[CH3:14][C:15]1[N:16]=[C:17]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[S:18][CH:19]=1>CCOCC>[Cl-:1].[F:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]([CH2:4][CH2:3][CH2:2][N+:23]2[CH:22]=[CH:21][C:20]([C:17]3[S:18][CH:19]=[C:15]([CH3:14])[N:16]=3)=[CH:25][CH:24]=2)=[O:6])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 197503-(4-Fluorobenzoyl)propyl chlorideHCID 409099HCID 409099, compound

Product 1

HCID 68130838HCID 68130838, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A 1.0 g. portion of γ-chloro-p-fluorobutyrophenone and 0.9 g. of 4-(4-methyl-2-thiazolyl)pyridine are heated in an oil bath at 95°-100°C. overnight. Ether is added and the mixture is filtered. The solid is recrystallized from acetonitrile. This solid is recrystallized from a mixture of alcohol and ether, m.p. 226°-228°C.

Workup

  1. filtrationthe mixture is filtered
  2. customThe solid is recrystallized from acetonitrile
  3. customThis solid is recrystallized from a mixture of alcohol and ether, m.p. 226°-228°C.

Sources & evidence

ORD record
ord-5559e48beb294fa8bfa793548511873d
Source dataset
uspto-grants-1976_06
Patent number
US03966748

Reaction notes

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