Phthalic Anhydride → HCID 10489043, compound

HRID 1658824Notes

Reaction equation

HRID 1658824 reaction equation
[NH2:1][CH:2]([CH2:5][CH3:6])[CH2:3][OH:4].[C:7]1(=O)[O:12][C:10](=[O:11])[C:9]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:8]12>C(O)(C)C>[C:7]1(=[O:12])[N:1]([CH:2]([CH2:5][CH3:6])[CH2:3][OH:4])[C:10](=[O:11])[C:9]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:8]12

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 221292-Amino-1-butanol

Product 1

HCID 10489043HCID 10489043, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

17.83 Gms. (0.2 mole) of 2-aminobutan-1-ol was added, with stirring, to a suspension of 29.62 gms. (0.2 mole) of phthalic anhydride in 90 mls. of isopropanol. The resulting mixture was refluxed for 18 hours. Thereafter, the isopropanol was distilled off under reduced pressure and the residue was distilled to give 38.1 gms. (yield 87%) of 2-phthalimidobutan-1-ol as a colourless viscous oil. (boiling point = 170° to 172°C./1 mm. Hg.)

Workup

  1. temperatureThe resulting mixture was refluxed for 18 hours
  2. distillationThereafter, the isopropanol was distilled off under reduced pressure
  3. distillationthe residue was distilled
  4. customto give 38.1 gms

Sources & evidence

ORD record
ord-ee1a70900f6142d198fa112fea922d0d
Source dataset
uspto-grants-1976_06
Patent number
US03966761

Reaction notes

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