Acetic Acid → HCID 54723677, compound

HRID 1658838Notes

Reaction equation

HRID 1658838 reaction equation
N1([C:6]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[S:9](=[O:17])(=[O:16])[CH2:8][C:7]=2[C:18]([O:20][C:21]2[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=2)=[O:19])CCCC1.Cl.C(O)(=[O:33])C>>[OH:33][C:6]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[S:9](=[O:17])(=[O:16])[CH2:8][C:7]=1[C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=1)=[O:19]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 21525735HCID 21525735, compound

Product 1

HCID 54723677HCID 54723677, compound

Procedure

A mixture of 7.0 g of p-nitrophenyl 4-(1-pyrrolidinyl)-2H-1-benzothiopyran-3-carboxylate 1,1-dioxide, 50 ml of glacial acetic acid, and 100 ml of 1N hydrochloric acid was heated on a steam bath for 20 min and diluted with ice-water. The resulting precipitate was collected and recrystallized from tetrahydrofuran-isopropyl ether to give 5.5 g of product, mp 206°-209° dec.

Workup

  1. temperaturewas heated on a steam bath for 20 min
  2. customThe resulting precipitate was collected
  3. customrecrystallized from tetrahydrofuran-isopropyl ether

Sources & evidence

ORD record
ord-c3100ce686644ab98745c3509cd0f95a
Source dataset
uspto-grants-1976_06
Patent number
US03966765

Reaction notes

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