Acetic Acid → HCID 21525721, compound

HRID 1658841Notes

Reaction equation

HRID 1658841 reaction equation
Cl.N[N:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6][C:5]2[CH:14]=[CH:15][CH:16]=[CH:17][C:4]1=2.[CH3:18][N:19]([CH3:22])[CH:20]=O.[CH2:23]([OH:25])[CH3:24].O.[C:27]([OH:30])(=O)[CH3:28]>>[CH:20]1[N:19]2[C:22]3[CH:4]=[CH:17][CH:16]=[CH:15][C:14]=3[CH2:5][CH2:6][C:7]3=[C:18]2[C:11](=[CH:12][CH:13]=[CH:8]3)[C:10]=1[CH2:9][N:3]1[C:23](=[O:25])[C:24]2=[CH:17][CH:4]=[CH:5][CH:6]=[C:28]2[C:27]1=[O:30]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 12268147HCID 12268147, compoundHCID 86633292ethanol water DMF

Product 1

HCID 21525721HCID 21525721, compound

Procedure

Following a procedure similar to that described in Example 1 and using 5-amino-10,11-dihydro-5H-dibenz[b,f]-azepine hydrochloride (5g.) and B-phthalimidopropaldehyde (4.1g.) in glacial acetic acid (75 ml.) there was obtained N-[(6,7-dihydroindolo[1,7-ab][1]benzazepine-2-yl)methyl] phthalimide (5.0g.), m.p. 190°-191°C. (dimethylformamide-ethyl alcohol-water/7.5:1:3).

Sources & evidence

ORD record
ord-2ee8709ccb6c454cabda22890680cec0
Source dataset
uspto-grants-1976_06
Patent number
US03966762

Reaction notes

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