HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1658843Generated: November 1, 2026
Hydrochloric Acid → 1-[3-(Chloromethyl)-4-hydroxyphenyl]ethan-1-one
https://huagongshe.com/reaction/1658843
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Product | 1-[3-(Chloromethyl)-4-hydroxyphenyl]ethan-1-one | HCID 2404811 | — |
Reaction Steps
To a mixture of 260 ml. of 37% formaldehyde and 1800 ml. of concentrated hydrochloric acid is added 400 g. of 4'-hydroxyacetophenone at a temperature of about 45°C. The mixture is maintained at 50°C. for two hours, filtered, and washed with water to give 3'-chloromethyl-4'-hydroxyacetophenone, m.p. 154° C. dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03966770 |
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| Source dataset | uspto-grants-1976_06 |
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| ORD ID | ord-c72cf416ab3146c88a5a3802f6b568cd |
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| Source note | uspto-grants-1976_06 |
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