反应详情

温度

50 °C

To a mixture of 260 ml. of 37% formaldehyde and 1800 ml. of concentrated hydrochloric acid is added 400 g. of 4'-hydroxyacetophenone at a temperature of about 45°C. The mixture is maintained at 50°C. for two hours, filtered, and washed with water to give 3'-chloromethyl-4'-hydroxyacetophenone, m.p. 154° C. dec.

1. additionTo a mixture of 260 ml
2. customat a temperature of about 45°C
3. filtrationfiltered
4. washwashed with water