反应详情

5-(4-Chlorobenzoyl)pentanoic acid (9.6g) was dissolved in dry toluene (80 ml) and thionyl chloride (10 ml) added. The reaction mixture was heated to reflux for 4 hours. The excess toluene and thionyl chloride were removed in vacuo, more toluene was added and again removed in vacuo affording 5-(4-chlorobenzoyl)pentanoyl chloride (10.4g 100%) as a pale brown solid.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 4 hours
3. customThe excess toluene and thionyl chloride were removed in vacuo, more toluene
4. additionwas added
5. customagain removed in vacuo