HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-ε-oxobenzenehexanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-(4-Chlorophenyl)-6-oxohexanoic acid | HCID 21939571 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-ε-oxobenzenehexanoyl chloride | HCID 13598899 | 100% |
Reaction Steps
5-(4-Chlorobenzoyl)pentanoic acid (9.6g) was dissolved in dry toluene (80 ml) and thionyl chloride (10 ml) added. The reaction mixture was heated to reflux for 4 hours. The excess toluene and thionyl chloride were removed in vacuo, more toluene was added and again removed in vacuo affording 5-(4-chlorobenzoyl)pentanoyl chloride (10.4g 100%) as a pale brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03966783 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-64a5c73ace12424abcd9badbd8c3a7de |
| Source note | uspto-grants-1976_06 |