Thionyl Chloride → HCID 13170170, compound

HRID 1658898Notes

Reaction equation

HRID 1658898 reaction equation
[O:1]=[C:2]([CH3:10])[CH2:3][CH2:4][CH2:5][CH2:6][C:7](O)=[O:8].S(Cl)([Cl:13])=O>CN(C)C=O.C1C=CC=CC=1>[O:1]=[C:2]([CH3:10])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([Cl:13])=[O:8]

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 988106-Oxoheptanoic acid

Product 1

HCID 13170170HCID 13170170, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 241BenzeneSolvent

Procedure

6-Oxo-heptanoic acid (20.1g; 0.14 mole), thionyl chloride (18.3g; 11.2 ml; 0.154 mole) and dry benzene (300 ml) together with dimethylformamide (three drops) were stirred at room temperature for 22 hours. The halogenating reagent and benzene were removed on the rotary evaporator. A further 100 ml of benzene was added and the solution was again evaporated under reduced pressure (to remove last traces of thionyl chloride). The quantitatively formed liquid acid chloride was used directly in step (b).

Workup

  1. customThe halogenating reagent and benzene were removed on the rotary evaporator
  2. additionA further 100 ml of benzene was added
  3. customthe solution was again evaporated under reduced pressure (to remove last traces of thionyl chloride)

Sources & evidence

ORD record
ord-927af213e0084ae2840d4061e571d211
Source dataset
uspto-grants-1976_06
Patent number
US03966783

Reaction notes

Loading…