HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ecgonine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate--hydrogen chloride (1/1) | HCID 162352 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ecgonine methyl ester | HCID 104904 | — |
Reaction Steps
To 20 ml of cold saturated potassium carbonate solution in a 125 ml separatory funnel was added a solution of 5.0 g (213 mmoles) ecgonine methyl ester hydrochloride in 5 ml water. The aqueous mixture was extracted with 4 × 50 ml of chloroform. The combined chloroform extracts were dried over anhydrous sodium carbonate and evaporated in vacuo. Pumping at 0.05 mm Hg for 15 minutes yielded 4.0 g (93%) of TLC pure (20:1, CHCl3 :MeOH) ecgonine methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03966764 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-9a9309b4f8f840eb93ea22472d51e604 |
| Source note | uspto-grants-1976_06 |