反应详情

To 20 ml of cold saturated potassium carbonate solution in a 125 ml separatory funnel was added a solution of 5.0 g (213 mmoles) ecgonine methyl ester hydrochloride in 5 ml water. The aqueous mixture was extracted with 4 × 50 ml of chloroform. The combined chloroform extracts were dried over anhydrous sodium carbonate and evaporated in vacuo. Pumping at 0.05 mm Hg for 15 minutes yielded 4.0 g (93%) of TLC pure (20:1, CHCl3 :MeOH) ecgonine methyl ester.

1. extractionThe aqueous mixture was extracted with 4 × 50 ml of chloroform
2. dry with materialThe combined chloroform extracts were dried over anhydrous sodium carbonate
3. customevaporated in vacuo