Methyl iodide → HCID 21526359, compound

HRID 1659075Notes

Reaction equation

HRID 1659075 reaction equation
[OH:1][CH:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[C:12]([NH2:22])[CH:11]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:23]I>N1C=CC=CC=1>[OH:1][CH:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[C:12]([NH:22][CH3:23])[CH:11]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 21526381HCID 21526381, compound

Product 1

HCID 21526359HCID 21526359, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.01 moles of ethyl α-hydroxy-γ-(3-amino-4-cyclohexylphenyl)butyrate in 100 ml. of pyridine is added 0.1 moles of methyl iodide. The reaction mixture is stirred overnight at room temperature, filtered and concentrated. The residue is distilled to obtain ethyl α-hydroxy-γ-(3-methylamino -4-cyclohexylphenyl)butyrate.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. distillationThe residue is distilled

Sources & evidence

ORD record
ord-946e59d4561f491bb848efccc44aba85
Source dataset
uspto-grants-1976_06
Patent number
US03966801

Reaction notes

Loading…