Potassium Hydroxide → HCID 21526657, compound

HRID 1659083Notes

Reaction equation

HRID 1659083 reaction equation
[OH-].[K+].[C:3]([OH:11])(=[S:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl[CH:13]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[Cl:31])=[CH:21][CH:20]=1)[C:14]([OH:16])=[O:15]>>[C:3]([S:10][CH:13]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[Cl:31])=[CH:21][CH:20]=1)[C:14]([OH:16])=[O:15])(=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 21525974HCID 21525974, compoundHCID 178526132HCID 178526132, compound

Product 1

HCID 21526657HCID 21526657, compound

Procedure

To 17.4 ml. of 2N alcoholic potassium hydroxide solution (0.035 mole) is added 4.84 g. (0.035 mole) of thiobenzoic acid. The solution is cooled to room temperature and to this is added in small portions 0.035 mole of α-chloro-γ-(2'-chloro-4-biphenylyl)butyric acid. The reaction mixture is stirred at room temperature for 25 hours, then the solvent is removed, the residue dissolved in ether, filtered and washed with cold water. The ethereal solution is then dried over magnesium sulfate and evaporated to dryness to obtain α-benzoylthio-γ-(2'-chloro-4-biphenylyl)butyric acid.

Workup

  1. customthe solvent is removed
  2. dissolutionthe residue dissolved in ether
  3. filtrationfiltered
  4. washwashed with cold water
  5. dry with materialThe ethereal solution is then dried over magnesium sulfate
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-041c425a02fd40e8bfdb3575c4be7127
Source dataset
uspto-grants-1976_06
Patent number
US03966801

Reaction notes

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