反应详情

To a cold stirred solution of 14.8 g. of monomethyl amine in 250 ml dry benzene was added (portionwise, keeping temperature below 10°), 19.5 g (0.0594 mole) of 2-bromo-4'-butoxy-2',6'-dimethyl propionanilide (made according to the procedure in the first part of this example); this dissolved readily, forming a clear solution. The mixture was heated to 70° for ca 1 hr. with stirring, at which point a white precipitate had separated and reflux became so vigorous that the reaction had to be controlled by external cooling.

1. customtemperature below 10°
2. dissolutionthis dissolved readily
3. customforming a clear solution
4. temperatureThe mixture was heated to 70° for ca 1 hr
5. customhad separated
6. temperaturereflux