Water → HCID 178467559, compound

HRID 1659100Notes

Reaction equation

HRID 1659100 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[C:11](=[C:14]([O:16]CC)[CH3:15])[S:10][C:9]2=[S:19])=[CH:4][CH:3]=1.O.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[C:11](=[C:14]([OH:16])[CH3:15])[S:10][C:9]2=[S:19])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86733628HCID 86733628, compound

Product 1

HCID 178467559HCID 178467559, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 32 g. (0.1 m.) of 3-(4'-chlorophenyl)-5-(1'-ethoxyethylidene)-rhodanine in 400 ml. of water and 250 ml. of methanol is added 85 ml. of 5% sodium hydroxide solution and the resulting suspension is stirred at room temperature for 5 hours. The reaction mixture is filtered and the filtrate is decolorized, then acidified with dilute hydrochloric acid to give 3-(4'-chlorophenyl)-5-(1'-hydroxyethylidene)-rhodanine, m.p. 200°-205°C.

Workup

  1. additionTo a mixture of 32 g
  2. filtrationThe reaction mixture is filtered

Sources & evidence

ORD record
ord-d368deafe939458686c33329670334d0
Source dataset
uspto-grants-1976_06
Patent number
US03966942

Reaction notes

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