HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → 3-Isopropyl-2-[O-(methylcarbamoyl) oximino]-4-thiazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 2-(Hydroxyimino)-3-(propan-2-yl)-1,3-thiazolidin-4-one | HCID 71396855 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Solvent | Acetone acetonitrile | HCID 21918305 | — |
| Product | 3-Isopropyl-2-[O-(methylcarbamoyl) oximino]-4-thiazolidinone | HCID 86733638 | — |
Reaction Steps
To a solution of 1.0 g of 3-isopropyl-2-oximino-4-thiazolidinone in 50 ml acetone-acetonitrile solution (1:1) was added 1 ml of methylisocyanate and 5 drops of triethylamine. The reaction mixture was placed in a pressure bottle and left overnight at ambient temperature. After concentrating under vacuo the residual oil was diluted with diethylether. On cooling the product crystallized. Recrystallized from ethyl ether. Weight 1.8 g. m.p. 94°-96°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03966953 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-a617895ddbfa447f9667cda27f19deeb |
| Source note | uspto-grants-1976_06 |