Hydrochloric Acid → HCID 21516781, compound

HRID 1659176Notes

Reaction equation

HRID 1659176 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[C:6]([Cl:18])[C:7]([CH3:17])=[C:8]([O:11][CH2:12][C:13]([O:15]C)=[O:14])[CH:9]=2)[C:4](=[O:19])[C:3]21[CH2:23][CH2:22][CH2:21][CH2:20]2.[OH-].[K+].CO.Cl>O>[O:1]=[C:2]1[C:10]2[C:5](=[C:6]([Cl:18])[C:7]([CH3:17])=[C:8]([O:11][CH2:12][C:13]([OH:15])=[O:14])[CH:9]=2)[C:4](=[O:19])[C:3]21[CH2:23][CH2:22][CH2:21][CH2:20]2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 86733640HCID 86733640, compound

Product 1

HCID 21516781HCID 21516781, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of methyl [1' ,3'-dioxo-4'-chloro-5'-methylspiro(cyclopentane-1,2'-indan)-6'-yloxy]acetate (3.5 g., 0.0104 mole) potassium hydroxide (0.67 g., 0.012 mole) and methanol (200 ml.) is refluxed for 1/2 hour, diluted with water (800 ml.) and acidified with hydrochloric acid affording 3.1 g. of [1' ,3'-dioxo-4'-chloro-5'-methylspiro(cyclopentane-1,2'-indan)-6'-yloxy]acetic acid which melts at 204°-5°C. after recrystallization from acetic acid-water.

Workup

  1. temperatureis refluxed for 1/2 hour
  2. customof [1' ,3'-dioxo-4'-chloro-5'-methylspiro(cyclopentane-1,2'-indan)-6'-yloxy]acetic acid which melts at 204°-5°C. after recrystallization from acetic acid-water

Sources & evidence

ORD record
ord-22a2b545dffb477480a77b0a6ed515fb
Source dataset
uspto-grants-1976_06
Patent number
US03966966

Reaction notes

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