HCID 20560022, compound → HCID 20560088, compound

HRID 1659251Notes

Reaction equation

HRID 1659251 reaction equation
[I-].C([NH:4][C:5]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:6]=1[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[CH3:15])=O.[I-].[N+](C1C=CC=CC=1C=CC1C=CC=C[N+]=1C)([O-])=O>Cl>[NH2:4][C:5]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:6]=1[CH2:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[CH3:15]

Participants

4

Reactant 2

HCID 20560022HCID 20560022, compoundHCID 667604421-Methyl-2-[2-(2-nitrophenyl)ethenyl]pyridin-1-ium iodide

Product 1

HCID 20560088HCID 20560088, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Catalytic reduction of 2-(2-formamido-5-methoxyphenethyl)-1-methylpyridinium iodide as described in Example 1 for 2-(o-nitrostyryl)-1-methylpyridinium iodide provides 2-(2-formamido-5-methoxyphenethyl)lmethylpiperidine. This material is deformylated in 1 N methanolic hydrogen chloride providing 2-(2-amino-5-methoxyphenethyl)-1-methylpiperidine.

Workup

  1. customprovides 2-(2-formamido-5-methoxyphenethyl)lmethylpiperidine

Sources & evidence

ORD record
ord-67c88498f34c44169bf6acdcebb49250
Source dataset
uspto-grants-1981_12
Patent number
USRE030812

Reaction notes

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