Hydrogen iodide → 2'-(2-Pyridylmethyl)-p-anisanilide

HRID 1659278Notes

Reaction equation

HRID 1659278 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH:16](O)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[O:8])=[CH:5][CH:4]=1.I>>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[NH:9][C:7](=[O:8])[C:6]1[CH:24]=[CH:25][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 24841Hydrogen iodideHCID 205600424-Methoxy-2'-[hydroxy(2-pyridyl)methyl]benzanilide

Product 1

HCID 205599902'-(2-Pyridylmethyl)-p-anisanilide

Procedure

Treatment of 4-methoxy-2'-[hydroxy(2-pyridyl)methyl]benzanilide with hydrogen iodide according to the procedure of Miller, et al., J. Org. Chem., 24, 1364 (1959) provides 2'-(2-pyridylmethyl)-p-anisanilide, m.p. 130.5°-131.5° C. (corr.), from methanol.

Sources & evidence

ORD record
ord-3d084fa21db94716b72792b7a9ad9c91
Source dataset
uspto-grants-1981_12
Patent number
USRE030812

Reaction notes

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