反应详情

A three-necked flask equipped with a stirrer, a reflux condenser and a thermometer was charged with 132 g of farnesylacetic acid, 140 g of triphenylphosphine and 500 ml of carbon tetrachloride, and the contents were heated under reflux of carbon tetrachloride for 4 hours. The reaction mixture was filtered to remove a formed solid matter, the carbon tetrachloride distilled off, 500 ml of n-hexane added, the mixture ice-cooled and the crystalline precipitate filtered off. The n-hexane was then distilled off, leaving 146 g of crude farnesylacetyl chloride.

1. customA three-necked flask equipped with a stirrer, a reflux condenser
2. temperaturethe contents were heated
3. filtrationThe reaction mixture was filtered
4. customto remove a formed solid matter
5. distillationthe carbon tetrachloride distilled off
6. addition500 ml of n-hexane added
7. temperaturethe mixture ice-cooled
8. filtrationthe crystalline precipitate filtered off
9. distillationThe n-hexane was then distilled off