反应详情

A three-necked flask equipped with a thermometer, a reflux condenser and a gas inlet tube was charged with 10 g of N,N-dimethyl-N'-farnesylacetylethylenediamine prepared by the procedure of Example 1 and 100 ml of acetonitrile. The contents were refluxed for 6 hours while methyl chloride was introduced. Thereafter, the methyl chloride and acetonitrile were distilled off and the remaining product was purified by column chromatography to give 8.6 g of farnesylacetylaminoethyltrimethylammonium chloride. The product was identified by proton NMR and elemental analysis. The NMR data were as follows:

1. customA three-necked flask equipped with a thermometer, a reflux condenser and a gas inlet tube
2. additionwas introduced
3. distillationThereafter, the methyl chloride and acetonitrile were distilled off
4. customthe remaining product was purified by column chromatography