Acetone → HCID 135737780, compound

HRID 1659330Notes

Reaction equation

HRID 1659330 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[CH:10][C:9]=1[N+:13]([O-:15])=[O:14].[CH3:16][C:17]([CH3:19])=O>C(O)(=O)C>[N+:13]([C:9]1[CH:10]=[N:11][N:12]2[C:8]=1[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:17]2([CH3:19])[CH3:16])([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 180AcetoneHCID 205602605-(o-Aminophenyl)-4-nitropyrazole

Product 1

HCID 135737780HCID 135737780, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 20.4 g (0.1 mole) of 5-(o-aminophenyl)-4-nitropyrazole, 300 ml of acetone and 0.3 ml of acetic acid is heated under reflux for 1 hour. After evaporation, 24.0 g (98.5%) of 1-nitro-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline are obtained. M.p.: 193°-195° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 1 hour
  3. customAfter evaporation, 24.0 g (98.5%) of 1-nitro-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline
  4. customare obtained

Sources & evidence

ORD record
ord-fec0379702d540f6b1abab26cb1f9859
Source dataset
uspto-grants-1981_12
Patent number
US04303660

Reaction notes

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