Hydrochloric Acid → HCID 53923779, compound

HRID 1659401Notes

Reaction equation

HRID 1659401 reaction equation
[CH3:1][NH:2][C:3](=[S:17])[NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[O:16])[C:11]([O:13]CC)=[O:12])[N:9]=1.CNC(=S)NC1NC(C(=O)C(OCC)=O)=CS1.[OH-].[Na+].Cl>O.C(O)C>[CH3:1][NH:2][C:3](=[S:17])[NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[O:16])[C:11]([OH:13])=[O:12])[N:9]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54335615Ethyl 2-[[(methylamino)thioxomethyl]amino]-α-oxo-4-thiazoleacetateHCID 86738140HCID 86738140, compound

Product 1

HCID 53923779HCID 53923779, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a mixture of ethyl 2-[2-[3-(methyl)thioureido]-1,3-thiazol-4-yl]glyoxylate, which can be represented as ethyl 2-[2-[3-(methyl)thioureido]-2,3-dihydro-1,3-thiazol-4-yl]glyoxylate, (21 g.), ethanol (200 ml) and water (100 ml.) was added 1 N sodium hydroxide aqueous solution (154 ml.) under ice-cooling and stirring. The mixture was further stirred for 10 minutes and then neutralized with 1 N hydrochloric acid (154 ml.). The precipitates were collected by filtration, washed with water and then dried to give 2-[2-[3-(methyl)thioureido]-1,3-thiazol-4-yl]glyoxylic acid, which can be represented as 2-[2-[3-(methyl)thioureido]-2,3-dihydro-1,3-thiazol-4-yl]glyoxylic acid, (17.8 g.), mp.>250° C.

Workup

  1. temperaturecooling
  2. stirringThe mixture was further stirred for 10 minutes
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-a8c2fdf6a9834398bae49495291e4e68
Source dataset
uspto-grants-1981_12
Patent number
US04303655

Reaction notes

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