Hydrochloric Acid → HCID 178517108, compound

HRID 1659439Notes

Reaction equation

HRID 1659439 reaction equation
C([O:4][CH2:5][C:6]1[NH:7][N:8]2[C:17]([CH:18]=1)=[C:16]1[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]1)=[N:10][C:9]2=[O:19])(=O)C.[OH-].[Na+].Cl.O>CO>[OH:4][CH2:5][C:6]1[NH:7][N:8]2[C:17]([CH:18]=1)=[C:16]1[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]1)=[N:10][C:9]2=[O:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 178475804HCID 178475804, compound

Product 1

HCID 178517108HCID 178517108, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The crude acetate product from Example 5 is slurried in a solution of 0.3 g of sodium hydroxide in 10 ml of aqueous methanol (1:1). After stirring for 5 hours, the reaction mixture is neutralized with concentrated hydrochloric acid followed by the addition of 13 ml of distilled water. After stirring overnight, the product is filtered, washed with cold distilled water and dried under vacuum at 60° C. to 0.62 g (72%) of white product, m.p. 285.0°-288.0° C.

Workup

  1. stirringAfter stirring overnight
  2. filtrationthe product is filtered
  3. washwashed
  4. distillationwith cold distilled water
  5. dry with materialdried under vacuum at 60° C. to 0.62 g (72%) of white product, m.p. 285.0°-288.0° C.

Sources & evidence

ORD record
ord-63efa3b241624c8daed7329202cba5c5
Source dataset
uspto-grants-1981_12
Patent number
US04303795

Reaction notes

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