Hydrochloric Acid → HCID 15578422, compound

HRID 1659501Notes

Reaction equation

HRID 1659501 reaction equation
[C:1]1([C:11](=[O:23])[CH2:12][C:13](=[O:22])[CH2:14][C:15](=O)[C:16]([O:18]CC)=[O:17])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.Cl>O1CCOCC1>[C:1]1([C:11]2[O:23][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13](=[O:22])[CH:12]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20447156HCID 20447156, compound

Product 1

HCID 15578422HCID 15578422, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

This crude ester was dissolved in dioxan (50 ml) and concentrated hydrochloric acid (50 ml), and the solution was heated under reflux for 11/2 hours then concentrated under vacuum to give a brown solid. The solid was recrystallised from ethanol and from ethanol-water to give the title product (mp 248°-249° C. with decomposition).

Workup

  1. temperatureunder reflux for 11/2 hours
  2. concentrationthen concentrated under vacuum
  3. customto give a brown solid
  4. customThe solid was recrystallised from ethanol and from ethanol-water

Sources & evidence

ORD record
ord-3df2fb0ed63f482dbec7cfb597c0c433
Source dataset
uspto-grants-1981_12
Patent number
US04304728

Reaction notes

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