Benzhydrylamine → HCID 12805911, compound

HRID 1659595Notes

Reaction equation

HRID 1659595 reaction equation
[CH:1]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH:18](Br)[CH3:19].C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C>[CH:1]([N:14]1[CH2:19][CH2:18][CH:17]1[CH3:16])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7036BenzhydrylamineHCID 78891,3-DibromobutaneHCID 10340Sodium Carbonate

Product 1

HCID 12805911HCID 12805911, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Combine benzhydrylamine (27.5 g=0.15 ml), 1,3-dibromobutane (40.5 g=0.19 mol) and sodium carbonate (28 g=0.33 mol) in 250 ml acetonitrile. Reflux 24 hours, allow to cool, filter and concentrate. Dissolve the residue in ether and wash with 1% sodium carbonate solution. Dry, concentrate and distill to obtain the product, boiling point 110°-115° C./0.1 mm pressure.

Workup

  1. temperatureReflux 24 hours
  2. temperatureto cool
  3. filtrationfilter
  4. concentrationconcentrate
  5. dissolutionDissolve the residue in ether
  6. washwash with 1% sodium carbonate solution
  7. customDry
  8. concentrationconcentrate
  9. distillationdistill
  10. customto obtain the product, boiling point 110°-115° C./0.1 mm pressure

Sources & evidence

ORD record
ord-b4f93fd6d287430091cacabf4e57c9de
Source dataset
uspto-grants-1981_12
Patent number
US04304790

Reaction notes

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