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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1659610Generated: October 26, 2026

1,4-Dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-3,5-pyridinedicarboxylic acid diethyl ester → Ethyl 1,4,5,6-Tetrahydro-2-methyl-4-(2-trifluoromethylphenyl)-5-oxo-6-(4-fluorophenyl)-7-phenyl-1,6-naphthyridine-3-carboxylate

https://huagongshe.com/reaction/1659610

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-3,5-pyridinedicarboxylic acid diethyl esterHCID 168089—
ReactantN-(4-fluorophenyl)-benzimidoyl chlorideHCID 12935376—
ProductEthyl 1,4,5,6-Tetrahydro-2-methyl-4-(2-trifluoromethylphenyl)-5-oxo-6-(4-fluorophenyl)-7-phenyl-1,6-naphthyridine-3-carboxylateHCID 20559740—

Reaction Steps

This product is obtained using the procedure of Example 1 from diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethyl-3,5-pyridine dicarboxylate and N-(4-fluorophenyl)-benzimidoyl chloride (2.5 g, 9.15%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04304914
Source datasetuspto-grants-1981_12
ORD IDord-81e6f90549ce4da5a69dd447ebc62fdb
Source noteuspto-grants-1981_12