Ammonia → Benzamide

HRID 1659657Notes

Reaction equation

HRID 1659657 reaction equation
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:9]([O-])([O-])=O.[Tl+].N.O=O>[Pd].O1CCOCC1>[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 222AmmoniaHCID 240BenzaldehydeHCID 977OxygenHCID 24937Thallous nitrate

Product 1

HCID 2331BenzamideYield 71%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 312751,4-DioxaneSolvent

Procedure

In the same flask as in Example 1 were charged 2 g of benzaldehyde, 50 g of dioxane as the reaction medium and 2 g of a catalyst in which 5 percent by weight of palladium metal together with thallium nitrate with an atomic ratio of Pd to Tl being 1 to 0.1. The reaction was conducted at a reaction temperature of 40° C. by introducing ammonia gas at a rate of 1 l/hour and oxygen at a rate of 10 l/hour at the same time into the flask for 2 hours to give benzamide at a yield of 71%.

Workup

  1. customwas conducted at a reaction temperature of 40° C.

Sources & evidence

ORD record
ord-dc3bbdcf87b943feab100c5a482ab73c
Source dataset
uspto-grants-1981_12
Patent number
US04304937

Reaction notes

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