Oxygen → N-Ethylnicotinamide

HRID 1659659Notes

Reaction equation

HRID 1659659 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[O:8])[CH:2]=1.[CH2:9]([NH2:11])[CH3:10].O=O>[Pd]>[CH2:9]([NH:11][C:7](=[O:8])[C:3]1[CH:4]=[CH:5][CH:6]=[N:1][CH:2]=1)[CH3:10]

Participants

5

Reactant 3

HCID 977OxygenHCID 6341EthylamineHCID 103713-Pyridinecarboxaldehyde

Product 1

HCID 78007N-EthylnicotinamideYield 47%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a 100 ml three-necked flask were charged 2 g of pyridine-3-aldehyde, 50 g of a 30 weight percent aqueous ethylamine solution and 3 g of the same commercially available palladium catalyst as in Example 1. The reaction was conducted at a reaction temperature of 30° C. for 2 hours by introducing oxygen at a rate of 10 l/hour into the flask from its gas inlet equipped with a filter to give nicotinic acid monoethylamide at a yield of 47%.

Workup

  1. customequipped with
  2. filtrationa filter

Sources & evidence

ORD record
ord-17723c827f74456db4a0cb4d50714e19
Source dataset
uspto-grants-1981_12
Patent number
US04304937

Reaction notes

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