Hydrochloric Acid → HCID 131712614, compound

Participants

Reaction Steps

A mixture of 2-methyl-7-[2-(2,2,2-trifluoroethoxyimino)-2-(2-formylaminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid (syn isomer) (0.8 g), concentrated hydrochloric acid (0.51 ml) and methanol (16 ml) was stirred for 2 hours at ambient temperature, and then evaporated. Thus obtained pale yellow residue was pulverized in diethyl ether, collected by filtration and then dried to give 2-methyl-7-[2-(2,2,2-trifluoroethoxyimino)-2-(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid hydrochloride (syn isomer) (0.8 g).

Provenance & Evidence