Hydrochloric Acid → HCID 131712614, compound

HRID 1659847Notes

Reaction equation

HRID 1659847 reaction equation
[CH3:1][CH:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[N:5]2[C:11](=[O:32])[CH:12]([NH:13][C:14](=[O:31])[C:15](=[N:24][O:25][CH2:26][C:27]([F:30])([F:29])[F:28])[C:16]3[N:17]=[C:18]([NH:21]C=O)[S:19][CH:20]=3)[C@H:4]2[S:3]1.[ClH:33]>CO>[ClH:33].[CH3:1][CH:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[N:5]2[C:11](=[O:32])[CH:12]([NH:13][C:14](=[O:31])[C:15](=[N:24][O:25][CH2:26][C:27]([F:29])([F:30])[F:28])[C:16]3[N:17]=[C:18]([NH2:21])[S:19][CH:20]=3)[C@H:4]2[S:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131712616HCID 131712616, compound

Product 1

HCID 131712614HCID 131712614, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-methyl-7-[2-(2,2,2-trifluoroethoxyimino)-2-(2-formylaminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid (syn isomer) (0.8 g), concentrated hydrochloric acid (0.51 ml) and methanol (16 ml) was stirred for 2 hours at ambient temperature, and then evaporated. Thus obtained pale yellow residue was pulverized in diethyl ether, collected by filtration and then dried to give 2-methyl-7-[2-(2,2,2-trifluoroethoxyimino)-2-(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid hydrochloride (syn isomer) (0.8 g).

Workup

  1. customevaporated
  2. filtrationcollected by filtration
  3. customdried

Sources & evidence

ORD record
ord-f24f18bd5b094b98b7aca497ed47b6da
Source dataset
uspto-grants-1981_12
Patent number
US04305937

Reaction notes

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