Epibromohydrin → 3-Isopropyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

HRID 1659892Notes

Reaction equation

HRID 1659892 reaction equation
[H-].[Na+].[CH:3]([C:6]1[CH:10]=[C:9]([CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[O:8][N:7]=1)([CH3:5])[CH3:4].[CH2:20]([CH:22]1[O:24][CH2:23]1)Br>>[CH:3]([C:6]1[CH:10]=[C:9]([CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH2:20][CH:22]2[O:24][CH2:23]2)[O:8][N:7]=1)([CH3:5])[CH3:4]

Participants

4

Reactant 3

HCID 18430EpibromohydrinHCID 24758Sodium hydrideHCID 1360819203-Isopropyl-5-(2-hydroxy-styryl)-isoxazole

Product 1

HCID 544590543-Isopropyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

Procedure

This is prepared, using the method described in Example VI, from 3.4 g of 55% strength sodium hydride (0.078 mole), 18 g (0.078 mole) of 3-isopropyl-5-(2-hydroxystyryl)-isoxazole and 10.8 g (0.078 mole) of epibromohydrin. 21.5 g (97% of theory) of a colorless oil are obtained.

Workup

  1. customThis is prepared
  2. custom21.5 g (97% of theory) of a colorless oil are obtained

Sources & evidence

ORD record
ord-beada3a2000943d893332687dbbc29c0
Source dataset
uspto-grants-1981_12
Patent number
US04305951

Reaction notes

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