HRID1659897

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7237

o-Xylene

C8H10

HCID8899

Laurylethanolamide

C14H29NO2

结构：CC(C)(C)c1cc(CCC(=O)O)cc(C(C)(C)C)c1O

HCID88389

Fenozan

C17H26O3

PRODUCTS

生成物

结构：CCCCCCCCCCCC(=O)NCCOC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1

HCID20558487

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-].[Ti+4]

催化剂HCID21801

Titanium(IV) n-butoxide

C16H36O4Ti

溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度: -10 °C

PROCEDURE

实验过程

A mixture of 13.9 g (0.055 mole) N-(2-hydroxyethyl)lauramide, 13.9 g (0.05 mole) 3(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid, 0.5 g Tyzor TBT catalyst and 100 ml xylene was refluxed until evolution of water ceased (3 hours). The xylene was removed by vacuum stripping. The residue was taken up in acetonitrile. White crystals separated upon cooling at about -10° C. The acetonitrile was decanted and the recrystallization was repeated. The last traces of acetonitrile were removed under vacuum, and the title product thus obtained was a yellow oil at room temperature.

WORKUP

后处理

custom(3 hours)
customThe xylene was removed by vacuum stripping
customWhite crystals separated
customThe acetonitrile was decanted
customthe recrystallization
customThe last traces of acetonitrile were removed under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3ff0b9801c74ba8b367eef2ae104c85
来源数据集: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04305868
来源说明: uspto-grants-1981_12

反应 SMILES

[OH:1][CH2:2][CH2:3][NH:4][C:5](=[O:17])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[C:18]([C:22]1[CH:23]=[C:24]([CH2:33][CH2:34][C:35](O)=[O:36])[CH:25]=[C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])[C:27]=1[OH:28])([CH3:21])([CH3:20])[CH3:19].C1(C)C(C)=CC=CC=1>CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-].[Ti+4].O>[C:29]([C:26]1[CH:25]=[C:24]([CH2:33][CH2:34][C:35]([O:1][CH2:2][CH2:3][NH:4][C:5](=[O:17])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:36])[CH:23]=[C:22]([C:18]([CH3:20])([CH3:19])[CH3:21])[C:27]=1[OH:28])([CH3:32])([CH3:30])[CH3:31]