反应详情

A mixture of 18.5 g. of 15-(trifluoromethyl)pentadecyl bromide, 17.0 g. of ethyl 4-aminobenzoate, 7.1 g. of potassium carbonate, and 75 ml. of hexamethylphosphoramide is stirred for 16 hours at 120° C., allowed to cool, diluted with water, and filtered. The solid is dissolved in methylene chloride and the solution is dried over anhydrous magnesium sulfate and evaporated. The residual brown oil is crystallized from ethanol and recrystallized from acetonitrile to yield the product as a white solid.

1. additionA mixture of 18.5 g
2. temperatureto cool
3. filtrationfiltered
4. dissolutionThe solid is dissolved in methylene chloride
5. dry with materialthe solution is dried over anhydrous magnesium sulfate
6. customevaporated
7. customThe residual brown oil is crystallized from ethanol
8. customrecrystallized from acetonitrile