反应详情

温度

40 °C

To 15 g. 4-[15-(trifluoromethyl)pentadecylamino]-benzoic acid in 200 ml. warm chloroform is added a solution of 15 g. of sodium carbonate in 150 ml. water. To the vigorously stirred solution is added 10 g. carbobenzyloxy chloride. After 2 hours stirring at 40° C., the layers are separated, washed three times with 1 N hydrochloric acid, dried, and evaporated to an oil. The oil is dissolved in 300 ml. toluene, treated with 15 ml. thionyl chloride and the solution is refluxed for 5 hours. The solvents are evaporated and the residue is dissolved three times in toluene, evaporating each time, ultimately to yield 4-[N-carbobenzyloxy-15-(trifluoromethyl)pentadecylamino]benzoyl chloride as a viscous, orange oil.

1. additionTo the vigorously stirred solution is added 10 g
2. customthe layers are separated
3. washwashed three times with 1 N hydrochloric acid
4. customdried
5. customevaporated to an oil
6. dissolutionThe oil is dissolved in 300 ml
7. additiontoluene, treated with 15 ml
8. temperaturethionyl chloride and the solution is refluxed for 5 hours
9. customThe solvents are evaporated
10. dissolutionthe residue is dissolved three times in toluene
11. customevaporating each time