2-Amino-2-methyl-1-propanol → HCID 13105031, compound

Participants

Reaction Steps

A mixture containing 12 g (0.05 mole) of 2 phenyl-4-chloroquinazoline, 4.5 g (0.05 mole) of 2-amino-2-methyl-1-propanol and 150 ml of isopropanol was refluxed for 4 hrs and filtered. The reaction mixture cooled to room temperature and filtered. The filtrate was concentrated to dryness under reduced pressure. The semi-solid residue was recrystallized with water to give 2.2 g of the title compound, m.p. 136°-138° C.

Provenance & Evidence