2-Amino-2-methyl-1-propanol → HCID 13105031, compound

HRID 1659952Notes

Reaction equation

HRID 1659952 reaction equation
[C:1]1([C:7]2[N:16]=[C:15](Cl)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][C:19]([CH3:23])([CH3:22])[CH2:20][OH:21]>C(O)(C)C>[CH3:22][C:19]([NH:18][C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:16]=1)([CH3:23])[CH2:20][OH:21]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 809774-Chloro-2-phenylquinazoline

Product 1

HCID 13105031HCID 13105031, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture containing 12 g (0.05 mole) of 2 phenyl-4-chloroquinazoline, 4.5 g (0.05 mole) of 2-amino-2-methyl-1-propanol and 150 ml of isopropanol was refluxed for 4 hrs and filtered. The reaction mixture cooled to room temperature and filtered. The filtrate was concentrated to dryness under reduced pressure. The semi-solid residue was recrystallized with water to give 2.2 g of the title compound, m.p. 136°-138° C.

Workup

  1. temperaturewas refluxed for 4 hrs
  2. filtrationfiltered
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure
  5. customThe semi-solid residue was recrystallized with water

Sources & evidence

ORD record
ord-0f547c2a639a44a79742dc0d729e1ed1
Source dataset
uspto-grants-1981_12
Patent number
US04306065

Reaction notes

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