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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1659958Generated: November 4, 2026

1-Fluoronaphthalene → 4-[4-(Naphthoxy)piperidinyl]-2-phenylquinazoline

https://huagongshe.com/reaction/1659958

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-FluoronaphthaleneHCID 9450—
ReactantSodium hydrideHCID 24758—
Reactant1-(2-Phenyl-4-quinazolinyl)-4-piperidinolHCID 12796030—
SolventDimethylformamideHCID 6228—
Product4-[4-(Naphthoxy)piperidinyl]-2-phenylquinazolineHCID 20506470—

Reaction Steps

Equimolar quantities of 4-(4-hydroxypiperidinyl)-2-phenylquinazoline, sodium hydride and 1-fluoronaphthalene are heated in dimethylformamide to prepare the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04306065
Source datasetuspto-grants-1981_12
ORD IDord-904950ade9ad4daea1188e1cb8c122f5
Source noteuspto-grants-1981_12